Research

General overview and Research Groups

The Turing Centre aims to stimulate a highly interdisciplinary community, especially physicists, mathematicians and computer scientists who, together with biologists, provide the means to base experimental studies on solid quantitative grounds, to identify new questions and conceptualize new ways of understanding the complexity of living systems.

Life is based on dynamic systems whose organizational principles remain unclear due to their complexity. Such complexity has different origins. Living systems are the product of a long evolutionary history and are intrinsically dynamic as they develop, renew their components, adapt to their physiological environments and are trained. This is illustrated for instance in the development of embryos and organs, and in the function of the immune and nervous systems.

Understanding biological complexity is one of the most significant challenges for the future. It will impact both basic research and medicine, since diseases emerge from anomalies in the organization and dynamics of living systems.

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The Turing Centre addresses the nature of the information underlying biological processes, and the organization and dynamics of biological structures. Five over-arching questions bringing together biologists interested in development, neuroscience and immunology along with physicists, computational biologists and mathematicians will underlie the research effort:

How does genetic information impact on cell fates?
How do signalling dynamics impact on cell differentiation?
How is information encoded in collective cellular dynamics?
How do networks of cell interactions form and function collectively?
How does mechanics impact on cell and tissue organization and dynamics?

CENTURI recruits researchers and post docs with backgrounds in computational biology, theoretical physics or biophysics, with a strong interest in working in a cross-disciplinary environment.

People and projects funded by CENTURI

Principal Investigators

Matthias Merkel (CPT)

Self-organization and collective effects in living systems

Hervé Rouault (CPT - INMED)

Neural networks for the representation of 3D environments

Phillipe Roudot (I2M)

Dynamic point cloud modeling for automated mining of molecular processes in 3D live cell microscopy

Pierre Ronceray (CPT)

Modeling and Measuring Soft Living Matter

Jean-François Rupprecht (CPT)

Out-of-equilibrium Mechanics (OM)

Paul Villoutreix (LIS)

Learning Meaningful Representations of Life

Léo Guignard (LIS)

Understanding developmental reproducibility at the single cell scale

 

Léo Guignard (LIS) - Understanding developmental reproducibility at the single cell scale

Matthias Merkel (CPT) - Self-organization and collective effects in living systems

Hervé Rouault (CPT - INMED) Neural networks for the representation of 3D environments

Pierre Ronceray (CPT) -Theoretical modeling and inference methods for the physics of
soft biological matter

Jean-François Rupprecht (CPT) - Out-of-equilibrium Mechanics (OM)

Paul Villoutreix (LIS) - Marseille Machine Learning Team

Philippe Roudot (I2M) - Dynamic point cloud modeling for automated mining of molecular processes in 3D live cell microscopy

Postdoctoral fellow

Shrisha Rao Balappa (CPT, INMED) - Study of the neural dynamics supporting internal spatial representations

Marie-Anne Burklein (Institut Fresnel - IBDM) - Smart-scans for live imaging of morphogenetic processes

Damien Courtine (CIML, I2M, MIO) - Deciphering chemical signals guiding T cells towards and in lymph node

Céline Dinet (IBDM, LCB)A Multiscale Analysis of Cell Polarity Transitions in a Bacterium

Clara Dussaux (INMED, CPT) - Long-term functional connectivity dynamics during brain development

Simon Gsell (IBDM, CPT) - Computational modeling of the interplay between cell differentiation and mechanics in embryoids

Stefan Harmansa (IBDM) - Emergence and Dissipation of Mechanical Stress during Epithelial Growth

Cheng-Tai Lee (CPT)Mechanics of disordered biopolymer networks

Nicolas Levernier (CPT, INMED) - Attractor neural networks and the resolution of a brain’s self-positioning system

Shao-Zhen Lin (CPT) - Hydrodynamic instabilities in curved environment

Maxime Lucas (IBDM, I2M, CPT) - A Multiscale Analysis of Cell Polarity Transitions in a Bacterium

Fabio Manca (LAI, CINaM)Modeling mechanosensing of T cells: from ligand-receptor bonds to cytoskeleton dynamics

Olivier Mesdjian (M2P2, CINAM)Long-range collective dynamics of cilia

Maria Mandela Prünster (IBDM, IMBE)Evolution of protein interactions

Jain Rikesh (LCB - IBDM)Functional and bioinformatics analysis of predator prey interaction in bacteria

Saswati Saha (TAGC) - Systems genetics: Developing new approaches integrating network analyses and modeling

Solène Song (LAI, CIML, LIS) - Deciphering chemical signals guiding T cells towards and in lymph node

Dmitrii Suchkov (INMED) - Multimodal exploration of pre-epileptic structural and circuit-levels changes in brain malformations

Nicolás Tizón-Escamilla (CPT) - What can we learn from fluctuations in living active materials?

Elisabeth Wieduwild (CIML, LAI) - Memory B cell dynamics in the skin

Francesca Zaccagnino (IBDM, I2M) - Contextualisation of signalling fluctuations

Shrisha Rao Balappa (CPT, INMED)

Study of the neural dynamics supporting internal spatial representations

Marie-Anne Burklen (Institut Fresnel - IBDM)

Smart-scans for live imaging of morphogenetic processes

Damien Courtine (CIML, I2M, MIO)

Global and local genome sequence analysis to understand fungal virulence

Céline Dinet (IBDM, LCB)

A Multiscale Analysis of Cell Polarity Transitions in a Bacterium

Clara Dussaux (INMED, CPT)

Long-term functional connectivity dynamics during brain development

Alexander Erlich (IRPHE, IBDM)

The mechanical basis of biological size control and growth termination

Stefan Harmansa (IBDM)

Emergence and Dissipation of Mechanical Stress during Epithelial Growth

Simon Gsell (IBDM, CPT)

Computational modeling of the interplay between cell differentiation and mechanics in embryoids

Cheng-Tai Lee (CPT)

Mechanics of disordered biopolymer networks

Nicolas Levernier (CPT, INMED)

Attractor neural networks and the resolution of a brain’s self-positioning system

Maxime Lucas (IBDM, I2M, CPT)

A Multiscale Analysis of Cell Polarity Transitions

Shao-Zhen Lin (CPT)

Hydrodynamic instabilities in curved environment

Fabio Manca (LAI, CINaM)

Modeling mechanosensing of T cells: from ligand-receptor bonds to cytoskeleton dynamics

Olivier Mesdjian (M2P2, CINAM)

Long-range collective dynamics of cilia

Maria Mandela Prünster (IBDM, IMBE)

Evolution of protein interactions

Jain Rikesh (LCB - IBDM)

Functional and bioinformatics analysis of predator prey interaction in bacteria

Saswati Saha (TAGC)

Systems genetics

Solène Song (LAI, CIML, LIS)

Deciphering chemical signals guiding T cells towards and in lymph node

Dmitrii Suchkov (INMED)

Multimodal exploration of pre-epileptic structural and circuit-levels changes in brain malformations

Nicolás Tizón-Escamilla (CPT)

What can we learn from fluctuations in living active materials?

Elisabeth Wieduwild (CIML, LAI)

Memory B cell dynamics in the skin

Francesca Zaccagnino (IBDM, I2M)

Contextualisation of signalling fluctuations

 

 

PhD students

Achyuth Acharya (IBDM, LAI)Instructing myofibrillogenesis in human muscle

Lama Awada (CIML, LAI)Imprint of mechanical forces on antibody affinity maturation in B cell immune responses

Athullya Baby (IBDM, CINaM, M2P2) - Quantitative analysis and simulation of fluid flows powered by cilia in vivo

Anthony Baptista (TAGC, MMG)Genetic and phenotypic comorbidities between Mendelian and common diseases

Katia Barret (IBDM, LAI, CPT)Mechanical environment and fate specification during mammalian morphogenesis

Julie Bavais (CIML, TAGC)Computational modelling of Innate Lymphoid Cell differentiation during embryogenesis

Elèna Brunet (IBDM, LMA)Unravelling the mechanisms underlying ultrasound stimulation of dorsal root and spiral ganglion neurons

Marie-Anne Burklen (Institut Fresnel - IBDM) -Smart-scans for live imaging of morphogenetic processes

Khulganaa Buyannemekh (IBDM, LIS)An interdisciplinary approach to the study of lateralization in the nervous system.

Lucas Curci (I2M, LAI)Mathematical modelling of cell migration in confined domains

Ammar Sabir Cheema (CIML, CPT)Deciphering the activation states of plasmacytoid dendritic cells

Sébastien Choteau (CIML - TAGC) - Understanding uORF functions through dendritic cells biology and computational approaches

Naveen Gajendra Kumar (INMED, Institut Fresnel)Visualizing deep hippocampus neuronal functional activity

Niels Gouirand (IBDM, CPT) - Deciphering the interplay between cell polarity and inter-cellular forces in epithelial 3D organization

Clara Guijarro (IBDM, LIS)Quantitative characterization of a cardiac progenitor cell epithelium

Simon Hadjaje (IUSTI, IBDM)Drosophila wing expansion for soft robotic application

Muhamet Ibrahimi (IBDM, CPT) Conditions for self-organized oriented deformation of biological tissue

Adrien Julia (LIS, INMED)Shape recognition and 3D visualization of neural circuitries from brain tissue clearing

Mark Karnat (CPT)- Deep-Learning Epithelial Tissue Mechanics (DELET’ME) project

Modar Malla (INMED, CPT, ISM) - Optimization of time and effort in decision and action: experiments meet theory

Mathieu Loizeau (IBDM, CPT)Functional transformations of sensory information in the brain

Thomas Morvan (INMED, IRPHE) - Studying algorithm(s) for decision making and confidence in an ethological framework

Varun Puthumana (CIML, M2P2) - Modeling T cell plasma membrane phase separation

Malek Senoussi (LIS) - A mathematical framework for morpho-transcriptomics eparation

Alla Solod (INMED, CPT)Understanding large-scale spatial navigation using virtual reality

Rémy Torro (CINAM, LAI)Mapping and classifying the topography of adhesive cell interface with high precision

Achyuth Acharya (IBDM, LAI)

Instructing myofibrillogenesis in human muscle

Lama Awada (CIML, LAI)

Imprint of mechanical forces on antibody affinity maturation in B cell immune responses

Athullya Baby (IBDM, CINaM, M2P2)

Quantitative analysis and simulation of fluid flows powered by cilia in vivo

Anthony Baptista (TAGC, MMG)

Genetic and phenotypic comorbidities

Katia Barret (IBDM, LAI, CPT)

Mechanical environment and fate specification during mammalian morphogenesis

Julie Bavais (CIML, TAGC)

Computational modelling of Innate Lymphoid Cell differentiation during embryogenesis

Elèna Brunet (IBDM, LMA)

Unravelling the mechanisms underlying ultrasound stimulation of dorsal root and spiral ganglion neurons

Khulganaa Buyannemekh (IBDM, LIS)

An interdisciplinary approach to the study of lateralization in the nervous system.

Lucas Curci (I2M, LAI)

Mathematical modelling of cell migration in confined domains

Ammar Sabir Cheema (CIML, CPT)

Deciphering the activation states of plasmacytoid dendritic cells

Sébastien Choteau (CIML - TAGC)

Understanding uORF functions 

Naveen Gajendra Kumar (INMED, Institut Fresnel)

Visualizing deep hippocampus neuronal functional activity

Niels Gouirand (IBDM, CPT)

Interplay between cell polarity and inter-cellular forces

Clara Guijarro (IBDM, LIS)

Quantitative characterization of a cardiac progenitor cell epithelium

Simon Hadjaje (IUSTI, IBDM)

Drosophila wing expansion for soft robotic application

Muhamet Ibrahimi (IBDM, CPT)

Conditions for self-organized oriented deformation of biological tissue

Adrien Julia (LIS, INMED)

Shape recognition and 3D visualization of neural circuitries from brain tissue clearing

Marc Karnat (CPT)

Deep-Learning Epithelial Tissue Mechanics (DELET’ME) project

Mathieu Loizeau (IBDM, CPT)

Functional transformations of sensory information in the brain

Modar Malla (INMED, CPT, ISM)

Optimization of time and effort in decision and action: experiments meet theory

Thomas Morvan (INMED, IRPHE)

Studying algorithm(s) for decision making

Varun Puthumana (CIML, M2P2)

Modeling T cell plasma membrane phase separation

Malek Senoussi (LIS)

A mathematical framework for morpho-transcriptomics 

Alla Solod (INMED, CPT)

Understanding large-scale spatial navigation using virtual reality

Anagha Surendranath (CINAM, I2M)

Deciphering the mechanotransductional effects in red blood cells
through interendothelial splenic slits

Rémy Torro (CINAM, LAI)

Mapping and classifying the topography of adhesive cell interface with high precision

Engineers

Sophie Brustlein - Optics & Biophotonics

Benoit Dehapiot - Image processing & data analysis

Guillaume Gay - Database management and data curation

Mathias Lechelon - Mechatronics

Stefania Sarno - Neuroscience data analyst

Qingzong Tseng - Image processing & data analysis

Thomas Vannier - Bioinformatics Data Analyst

Muhammad Asif

Bioinformatics Data Analyst

Sophie Brustlein

Optics & Biophotonics

 

Benoit Dehapiot

Image processing & data analysis

Guillaume Gay

Database management and data curation

Mathias Lechelon

Mechatronics

Thomas Vannier

Bioinformatics Data Analyst

Stefania Sarno

Data Neuroscientist 

 

Alumni

Charlotte Rulquin (IBDM) - Postdoctoral fellow - Computational study of cell pattern emergence

Masoud A. SharbafSoftware developer & data analyst

Clara Sidor (IBDM, institut Fresnel) - Postdoctoral fellow - Muscle building: Bridging molecular order to macroscopic morphogenesis

Sham Tlili (IBDM - CPT - LAI) - Postdoctoral fellow - Mechanics of gastrulation in mammals using a minimal in vitro system

Charlotte Rulquin (IBDM)

Postdoctoral fellow

Computational study of cell pattern emergence

Masoud A. Sharbaf

Software developer & data analyst

Clara Sidor (IBDM, institut Fresnel)

Postdoctoral fellow

Muscle building

Sham Tlili (IBDM - CPT - LAI)

Postdoctoral fellow

Mechanics of gastrulation in mammals 

Qingzong Tseng

Engineer fellow

Image processing & data analysis

 

Photography by ©Criscuolo

Publications

2021

  • Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry. Lavalou J, Mao Q, Harmansa S, Kerridge S, Lellouch AC, Philippe JM, Audebert S, Camoin L, Lecuit T. Dev Cell. 2021 Apr 27:S1534-5807(21)00270-7. doi: 10.1016/j.devcel.2021.03.030. Online ahead of print. PMID: 33932333
  • Distinct actin-dependent nanoscale assemblies underlie the dynamic and hierarchical organization of E-cadherin. Chandran R, Kale G, Philippe JM, Lecuit T, Mayor S. Curr Biol. 2021 Apr 26;31(8):1726-1736.e4. doi: 10.1016/j.cub.2021.01.059. Epub 2021 Feb 18. PMID: 33607036
  • Programmed and self-organized flow of information during morphogenesis. Collinet C, Lecuit T. Nat Rev Mol Cell Biol. 2021 Apr;22(4):245-265. doi: 10.1038/s41580-020-00318-6. Epub 2021 Jan 22. PMID: 33483696 Review. 

2020

  • Neuronal specification in elegans: combining lineage inheritance with intercellular signaling. Barrière A. and Bertrand V. (2020). J. Neurogenetics 34, 273-81. DOI : 10.1080/01677063.2020.1781850.
  • Wnt ligands regulate the asymmetric divisions of neuronal progenitors in elegans embryos. Kaur S., Mélénec P., Murgan S., Bordet G., Recouvreux P., Lenne P.F. and Bertrand V. (2020). Development 147, dev183186.
  • Long-read only assembly of Drechmeria coniospora genomes reveals widespread chromosome plasticity and illustrates the limitations of current nanopore methods. Courtine D, Provaznik J, Reboul J, Blanc G, Benes V, Ewbank JJ.. Gigascience. 2020 Sep 18;9(9):giaa099. doi: 10.1093/gigascience/giaa099.
  • Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development. Weaver BP, Weaver YM, Omi S, Yuan W, Ewbank JJ, Han MDev Cell. 2020 May 4;53(3):358-369.e6. doi: 10.1016/j.devcel.2020.03.015. Epub 2020 Apr 16. PMID: 32302544.
  • Fabrication of sharp silicon arrays to wound Caenorhabditis elegans. Belougne J, Ozerov I, Caillard C, Bedu F, Ewbank JJ. Sci Rep. 2020 Feb 27;10(1):3581. doi: 10.1038/s41598-020-60333-7. PMID: 32108170.
  • Microtubule plus-end dynamics link wound repair to the innate immune response. Taffoni C, Omi S, Huber C, Mailfert S, Fallet M, Rupprecht JF, Ewbank JJ, Pujol N. Elife. 2020 Jan29;9:e45047. doi: 10.7554/eLife.45047. PMID: 31995031.
  • New Strains for Tissue-Specific RNAi Studies in Caenorhabditis elegans. Watts JS, Harrison HF, Omi S, Guenthers Q, Dalelio J, Pujol N, Watts JL. G3 (Bethesda). 2020 Nov 5;10(11):4167-4176. doi: 10.1534/g3.120.401749. PMID: 32943454.
  • IL-17: good fear no tears. Rua R, Pujol N. Nat Immunol. 2020 Nov;21(11):1315-1316. doi: 10.1038/s41590-020-0792-4. PMID: 32958929.
  • Diversity from Similarity: Cellular Strategies for Assigning Particular Identities to Actin Filaments and Networks. Boiero Sanders M., Antkowiak A., Michelot A*. Open Biol. 2020 Sep;10(9):200157. doi: 10.1098/rsob.200157.
  • Force Production by a Bundle of Growing Actin Filaments is Limited by its Mechanical Properties. Martiel J.L., Michelot Alphée, Boujemaa-Paterski R., Blanchoin L., Berro J.. Biophys J. 2020 Jan 7;118(1):182-192. doi: 10.1016/j.bpj.2019.10.039.
  • Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability. Dehapiot, B., Clément, R., Alégot, H. et al.  Nat Cell Biol (2020). https://doi.org/10.1038/s41556-020-0524-x.
  • Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors. Genovese S, Clément R, Gaultier C, Besse F, Narbonne-Reveau K, Daian F, Foppolo S, Luis NM, Maurange Elife. 2019 Sep 30;8:e50375. doi: 10.7554/eLife.50375. PMID: 31566561.
  • Towards a general framework for spatio-temporal transcriptomics – LMRL Workshop, Neurips 2020 - J. Pinol, T. Artières, P. Villoutreix. Youtube link.
  • Human neutrophils swim and phagocytise bacteria. Garcia-Seyda N, Seveau V, Manca F, Biarnes-Pelicot M, Valignat M-P, Bajénoff M and Theodoly O*. Biology of the Cell, doi: 10.1111/boc.202000084.
  • Amoeboid Swimming Is Propelled by Molecular Paddling in Lymphocytes. Aoun L; Farutin, A; Garcia-Seyda, N; Negre, P; Rizvi, MS; Tlili, S (Tlili, Sham)[ 1,4 ] ; Song, S (Song, Solene)[ 1 ] ; Luo, X; Biarnes-Pelicot, M; Galland, R; Sibarita, JB ; Michelot; Hivroz, C; Rafai, S; Valignat, MP ; Misbah*, C; Theodoly, O*, Biophysical Journal, 119, 6,1157-1177, doi: 10.1016/j.bpj.2020.07.033.
  • Lymphocytes perform reverse adhesive haptotaxis mediated by LFA-1 integrins. Luo, X ; de Noray, VS ; Aoun, L; Biarnes-Pelicot, M ; Strale, PO; Studer, V; Valignat, MP; Theodoly, O*. Journal of Cell Science, 133, 16, Article Number: jcs242883, DOI: 10.1242/jcs.242883, 2020.
  • Three-dimensional imaging with reflection synthetic confocal microscopy. Rasedujjaman, M ; Affannoukou, K; Garcia-Seyda, N; Robert, P; Giovannini, H  ; Chaumet, PC; Theodoly O; Valignat, MP; Belkebir,; Sentenac, A; Guillaume Maire . Optics Letters 2020, 45, 13, 3721-3724. doi: 10.1364/OL.397364.
  • Microfluidic device to study flow-free chemotaxis of swimming cells. Garcia-Seyda N, Aoun L, Tishkova V, Seveau V, Biarnes-Pelicot M, Bajenoff M, Valignat MP, Olivier Theodoly* Chip. 2020;20(9):1639–1647, (2020). doi: 10.1039/d0lc00045k.
  • A Bistable Mechanism Mediated by Integrins Controls Mechanotaxis of Leukocytes. A. Hornung, T. Sbarrato, N. Garcia-Seyda, L. Aoun, X. Luo, M. Biarnes-Pelicot, Theodoly*, MP. Valignat*. Biophys. J. 2020;118(3):565–577, (2020). DOI: 10.1016/j.bpj.2019.12.013.
  • Deterministic and Stochastic Rules of Branching Govern Dendrite Morphogenesis of Sensory Neurons. Palavalli A, Tizón-Escamilla N, Rupprecht JF, Lecuit T. Curr Biol. 2021 Feb 8;31(3):459-472.e4. doi: 10.1016/j.cub.2020.10.054. Epub 2020 Nov 18. 
  • Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion. A. P. Le, J.-F. Rupprecht, R.-M. Mège, Y. Toyama, C. T. Lim, B. Ladoux, Nature Communications (2020).
  • Embryonic geometry underlies phenotypic variation in decanalized conditions. A. Huang, J.-F. Rupprecht and T. E. Saunders eLife (2020).
  • Measuring social networks in primates: wearable sensors vs. direct observations, V. Gelardi, J. Godard, D. Paleressompoulle, N. Claidière, A. Barrat, Proc. R. Soc. A 476:20190737 (2020)
  • Relevance of temporal cores for epidemic spread in temporal networks, M. Ciaperoni, E. Galimberti, F. Bonchi, C. Cattuto, F. Gullo, A. Barrat, Scientific Reports 10:12529 (2020)
  • Dynamic core periphery structure of information sharing networks in entorhinal cortex and hippocampus, N. Pedreschi, C. Bernard, W. Clawson, P. Quilichini, A. Barrat, D. Battaglia, Network Neuroscience 4:946 (2020)
  • Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance. Lamballe F., Ahmad F., Vinik Y., Castellanet O., Daian F., Müller A.K., Köhler U.A., Bailly A.L., Josselin E., Castellano R. Cayrou C., Charafe-Jauffret E., Mills G.B., Géli V., Borg J.P., Lev S., Maina F. Advanced Science, Dec 16;8(3):2003049 (2020). PMID: 33552868.
  • Enhanced differentiation of human induced pluripotent stem cells towards the midbrain dopaminergic neuron lineage through GLYPICAN-4 down regulation. Corti S., Bonjean R., Rattier D., Legier T., Melon C., Salin P., Toso E.A., Kyba M., Kerkerian-Le Goff L., Maina F., Dono R. Stem Cells Translational Medicine, Feb 2 (2021). PMID: 33528918.
  • C3G is upregulated in hepatocarcinoma, contributing to tumor growth and progression and to HGF/MET pathway activation. Sequera C., Bragado P., Manzano S., Arechederra M., Richelme S., Gutiérrez-Uzquiza A., Sánchez A., Maina F., Guerrero C., Porras A. Cancers, Aug 14;12(8):2282 (2020). PMID: 32823931.
  • The Dorsal Striatum Energizes Motor Routines. Jurado-Parras MT, Safaie M, Sarno S, Louis J, Karoutchi C, Berret B, Robbe D. Current biology : CB - Sep 2020
  • Turning the body into a clock: Accurate timing is facilitated by simple stereotyped interactions with the environment. Mostafa SafaieMaria-Teresa Jurado-Parras, Stefania SarnoJordane LouisCorane KaroutchiLudovic F. PetitMatthieu O. Pasquet, Christophe Eloy, and David Robbe.
  • The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection. Abbas A, Vu Manh TP, Valente M, Collinet N, Attaf N, Dong C, Naciri K, Chelbi R, Brelurut G, Cervera-Marzal I, Rauwel B, Davignon JL, Bessou G, Thomas-Chollier M, Thieffry D, Villani AC, Milpied P, Dalod M, Tomasello E. Nat Immunol. 2020. doi: 10.1038/s41590-020-0731-4.
  • The quest for faithful in vitro models of human dendritic cells types. Luo XL, Dalod M. Mol Immunol. 2020. doi: 10.1016/j.molimm.2020.04.018.
  • Anisotropy links cell shapes to tissue flow during convergent extension.  Xun Wang,  Matthias Merkel, Leo B. Sutter, Gonca Erdemci-Tandogan,  M. Lisa Manning, and Karen E. Kasza. PNAS June 16, 2020 117 (24) 13541-13551; first published May 28, 2020; https://doi.org/10.1073/pnas.1916418117.
  • An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity. Ghislat G, Cheema AS, Baudoin E, Verthuy C, Ballester PJ, Crozat K, Attaf N, Dong C, Milpied P, Malissen B, Auphan-Anezin N, Vu Manh TP, Dalod M, Lawrence T. bioRxiv 2020.12.28.424621; doi: https://doi.org/10.1101/2020.12.28.424621.
  • Active mucus–cilia hydrodynamic coupling drives self-organization of human bronchial epithelium.Loiseau, E., Gsell, S., Nommick, A. et al.  Nat. Phys. (2020). https://doi.org/10.1038/s41567-020-0980-z.
  • NK cells orchestrate splenic cDC1 migration to potentiate antiviral protective CD8+ T cell responses. Ghilas S, Ambrosini M, Cancel JC, Massé M, Lelouard H, Dalod M, Crozat K.  bioRxiv 2020.04.23.057463; doi: https://doi.org/10.1101/2020.04.23.057463.
  • cDC1 and interferons promote spontaneous CD4+ and CD8+ T cell protective responses to breast cancer. Mattiuz R, Brousse C, Ambrosini M, Cancel JC, Bessou G, Mussard J, Sanlaville A, Caux C, Bendriss-Vermare N, Valladeau-Guilemond J, Dalod M, Crozat K. bioRxiv 2020.12.23.424092; doi: https://doi.org/10.1101/2020.12.23.424092
  • Networks beyond pairwise interactions: Structure and dynamics. Federico Battiston, Giulia Cencetti, Iacopo Iacopini, Vito Latora, Maxime Lucas, Alice Patania, Jean-Gabriel Young, and Giovanni Petri. Physics Reports, 874:1--92, 2020. Networks beyond pairwise interactions: Structure and dynamics. 
  • Hippocampal hub neurons maintain distinct connectivity throughout their lifetime. Bocchio M, Gouny C, Angulo-Garcia D, Toulat T, Tressard T, Quiroli E, Baude A, Cossart R. Nat Commun. 2020 Sep 11;11(1):4559. doi: 10.1038/s41467-020-18432-6. PMID: 32917906 Free PMC article.
  • Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Xing Zhang, Benjamin Harding, Dina Aggad, Damien Courtine, Jia-Xuan Chen, Nathalie Pujol, and Jonathan Ewbank.
  • Multiorder laplacian for synchronization in higher-order networks. Maxime Lucas, Giulia Cencetti, and Federico Battiston. Phys. Rev. Research, 2:033410, Sep 2020.
  • DeepCINAC: A Deep-Learning-Based Python Toolbox for Inferring Calcium Imaging Neuronal Activity Based on Movie Visualization. Denis J, Dard RF, Quiroli E, Cossart R, Picardo MA. eNeuro. 2020 Aug 17;7(4):ENEURO.0038-20.2020. doi: 10.1523/ENEURO.0038-20.2020. Print 2020 Jul/Aug. PMID: 32699072.
  • GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex. Duan ZRS, Che A, Chu P, Modol L, Bollmann Y, Babij R, Fetcho RN, Otsuka T, Fuccillo MV, Liston C, Pisapia DJ, Cossart R, De Marco García NV. Neuron. 2020 Jan 8;105(1):75-92.e5. doi: 10.1016/j.neuron.2019.10.008. Epub 2019 Nov 25. PMID: 31780329 Free PMC article.
  • Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex. Modol L, Bollmann Y, Tressard T, Baude A, Che A, Duan ZRS, Babij R, De Marco García NV, Cossart R. Neuron. 2020 Jan 8;105(1):93-105.e4. doi: 10.1016/j.neuron.2019.10.007. Epub 2019 Nov 25. PMID: 31780328 Free PMC article.

2019

  • Self-organization of red blood cell suspensions under confined 2D flows. C. Iss, D. Midou, A. Moreau, D. Held, A. Charrier, S. Mendez, A. Viallat#, Helfer#. Soft Matter 15, 2971 (2019)
  • White blood cells dynamics in micro-flows. A. Viallat, J. Dupire, Helfer. In : Blood Cells Suspension Dynamics in Microflows, CRC Press (2019)
  • Are Conventional Type 1 Dendritic Cells Critical for Protective Antitumor Immunity and How? Cancel JC, Crozat K, Dalod M, Mattiuz R.  Front Immunol. 2019;10:9. doi: 10.3389/fimmu.2019.00009.
  • A minimal-length approach unifies rigidity in underconstrained materials. Matthias Merkel, Karsten Baumgarten, Brian P. Tighe, M. Lisa Manning. Proceedings of the National Academy of Sciences Apr 2019, 116 (14) 6560-6568; DOI: 10.1073/pnas.1815436116
  • Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles. Sauerwald J, Backer W, Matzat T, Schnorrer F, Luschnig S. eLife. pii: e48857. doi: 10.7554/eLife.48857.
  • A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo. Lemke SB, Weidemann T, Cost AL, Grashoff C, and Schnorrer F. (2019). PLoS Biology. 17(3):e3000057. doi: 10.1371/journal.pbio.3000057
  • 1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo. Morgan PJ, Bourboulou R, Filippi C, Koenig-Gambini J, Epsztein J. Elife. 2019 Nov 27;8.
  • Dynamic control of hippocampal spatial coding resolution by local visual cues. Bourboulou R, Marti G, Michon FX, El Feghaly E, Nouguier M, Robbe D, Koenig J, Epsztein J. Elife. 2019 Mar 1;8
  • Genetic induction and mechanochemical propagation of a morphogenetic wave; Baille, A, Collinet C, Philippe JM, Lenne PF, Munro E, Lecuit T. Nature. 2019 Aug;572(7770):467-473. doi: 10.1038/s41586-019-1492-9. Epub 2019 Aug 15. PMID: 31413363
  • Experimental validation of force inference in epithelia from cell to tissue scale; Kong W, et al. Sci Rep 2019. PMID 31601854
  • Mechanical Stiffness of Reconstituted Actin Patches Correlates Tightly with Endocytosis Efficiency. PLANADE J, BELBAHRI R, BOEIRO SANDERS M, GUILLOTIN A, DU ROURE O, MICHELOT A*, HEUVINGH J. PLoS Biol. 2019 Oct 25 ;17(10) :e3000500
  • Sizes of actin networks sharing a common environment are determined by the relative rates of assembly. ANTKOWIAK A, GUILLOTIN A, BOEIRO SANDERS M, COLOMBO J, VINCENTELLI R, MICHELOT A*. PLoS Biol. 2019 Jun 10 ;17(6) :e3000317
  • Internal representation of hippocampal neuronal population spans a time-distance continuum. Haimerl C, Angulo-Garcia D, Villette V, Reichinnek S, Torcini A, Cossart R, Malvache A. Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7477-7482. doi: 10.1073/pnas.1718518116
  • Distinct RhoGEFs activate apical and junctional actomyosin contractility under control of G proteins during epithelial morphogenesis. Alain Garcia De Las Bayonas, Jean-Marc Philippe, Annemarie C. Lellouch, Thomas Lecuit. Current Biology. 2019 Oct 21;29(20):3370-3385.e7. DOI: 10.1016/j.cub.2019.08.017

2018

  • Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis.Kale GR, Yang X, Philippe JM, Mani M, Lenne PF, Lecuit T. Nat Commun. 2018 Nov 27;9(1):5021. doi: 10.1038/s41467-018-07448-8. PMID: 30479400
  • Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo. Mattiuz R, Wohn C, Ghilas S, Ambrosini M, Alexandre YO, Sanchez C, Fries A, Vu Manh TP, Malissen B, Dalod M, Crozat K.  Front Immunol. 2018;9:2805. doi: 10.3389/fimmu.2018.02805.
  • Quantitative Control of GPCR Organization and Signaling by Endocytosis in Epithelial Morphogenesis. Jha A, van Zanten TS, Philippe JM, Mayor S, Lecuit T., Curr Biol. 2018 May 21;28(10):1570-1584.e6. doi: 10.1016/j.cub.2018.03.068. Epub 2018 May 3.
  • Strengthen Your Junctions to Resist the Force. Lellouch AC, de Las Bayonas AG, Lecuit T. Dev Cell. 2018 Nov 19;47(4):406-407. doi: 10.1016/j.devcel.2018.11.007. PMID: 30458136
 
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