Olivier Mesdjian

Long-range collective dynamics of cilia, mucus transport and tissue polarity in bronchial epithelium

Team: Julien Favier (M2P2) - Annie Viallat (CINaM)

His background

September 2019 - present | CENTURI postdoctoral fellow

2016 - 2018 | Postdoctoral fellow - ENS Paris

2018 - 2019 | Teacher - Bergson high school (Paris)

2018 | Postdoctoral fellow - Laboratory of Physics and Mechanics of Heterogeneous Media (Paris)

2015 - 2017 | PhD - Institut Pierre-Gilles de Gennes for the Microfluidics (Paris)

2012 - 2014 | MSc Physics, Soft matter and fluid mechanics, concepts and applications - ENS LYON

About his postdoctoral project

Airway epithelium is protected by the active transport at its surface of a layer of a complex fluid, the mucus. It is powered by the coordinated beats characterized by a strong long-range orientational order of billions of microscopic cilia carried by epithelial cells. Recently, we experimentally showed that, during ciliogenesis, large milling patterns of ciliary beats leading to mucus vortex flows spontaneously emerged on reconstituted epitheliums and that the removal of mucus and further addition of model fluids could destroy and reconstitute this order, respectively. Our objectives are to understand the emergence and the maintain of the collective dynamic order of ciliary beats, which involve the mechanical cilia-mucus coupling mediated by long-range hydrodynamic interactions, and the active mechanotransductive response of ciliary beats. We propose to combine an in-vitro experimental approach on cultures at Air Liquid Interface and an in-silico approach based on Lattice Boltzmann simulations to build a reliable numerical model of mucus transport.