Clara Sidor (IBDM - Institut Fresnel)

Muscle building: Bridging molecular order to macroscopic morphogenesis

Team: Franck Schnorrer (IBDM) - Sophie Brasselet (Institut Fresnel)

Her background

May 2019 - present | CENTURI postdoctoral fellow

2018 - 2019 | Postdoctoral fellow, Francis Crick Institute (London, UK)

2013 - 2018 | Postdoctoral fellow, University of Cambridge (Cambridge, UK)

2007 - 2012 | PhD in Developmental Signaling, University College London (London, UK)

2005 - 2007 | MSc degree in Molecular and Cellular Biology - Université Pierre et Marie Curie (Paris, France)

About her postdoctoral project

Sarcomeres  are  force-­‐generating  and  load-­‐bearing  devices  of  muscle.  Each  sarcomere  contains  a  pseudo-­‐crystalline order of bipolar actin, myosin and titin filaments. During development sarcomeres assemble into long  periodic  chains  called  myofibrils  that  span  the  entire  muscle.  How  sarcomeric  components  organize  into molecularly ordered structures (molecular order) while assembling long myofibrils (macroscopic order) is an important unsolved question. Here, we will use genetic, mechanical and advanced imaging approaches to tackle this question. The recruited postdoc will implement a live imaging approach based on polarization resolved  microscopy  to  probe  the  molecular  order  of  sarcomeric  components  in  developing  Drosophila  muscles in vivo and human iPS-­‐derived muscles in vitro, and test the role of tension for order generation. The  originality  of  the  project  relies  on  the  integration  of  quantitative  approaches  to  bridge  from  the  molecular to the macroscopic scale to explain how large muscle fibers build their contractile machines.

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