Shape recognition and 3D visualization of neural circuitries from brain tissue clearing
Team: Djamal MERAD (LIS) - Valéry MATARAZZO (INMED) - Christophe PELLEGRINO (INMED)
October 2020 - present | CENTURI PhD student
2018 - 2019 | MSc IPSI - Signal processing - Aix-Marseille Université - Ecole Centrale Marseille (Marseille)
2016 - 2018 | MSc SPaCE - Laboratoire d’Astrophysique de Marseille (LAM) (France)
2013 - 2016 | BSc in Physics - Aix-Marseille Université (France)
About his PhD project
Neural networks connectivity is crucial to elucidate how the brain process information during behavioral tasks. The project we propose is to dissect out the anatomical link that exists between the prefrontal cortex and the hippocampus in the frame of social behavior in physiologic and pathologic conditions.
Although a new momentum in neural circuitry visualization has appeared with recent development of new tissue clearing methods, a combined effort between neurobiologists and computer scientists is now required for processing, modeling and analyzing.
The retained candidate with background in informatics and image processing will model the prefontal cortex to hippocampus interaction map using bank of images obtained from brain tissue clearing and light sheet microscopy. One of the originalities of our work is to allow comprehension from the analysis and the recognition of the acquired information until the problems of visualization of the modeled objects.