Yan Plötze
Characterizing the Growth Dynamics and Spatial Coverage of Drosophila Sensory Neurons
Team: Rupprecht group (CPT, Aix-Marseille Université) & Lecuit lab (IBDM)
His background
2022 - 2024 | Master of Physics, Aix-Marseille Université (tracks: dynamical/living/complex systems; soft & condensed matter; statistical physics; continuous media)
2018 - 2021 | BSc in Physics, Université de Strasbourg & Aix-Marseille Université
2018 - 2022 | BSc in Mathematics (free auditor, AMU/Unistra)
About his PhD Project
I study how Drosophila melanogaster sensory neurons grow and organize their dendritic arbors to efficiently cover space. Using live imaging, analytical modeling and numerical simulations, I focus on class IV dendritic arborization neurons (nociception), whose dendrites expand in a quasi-2D environment and fill space homogeneously. Taking a coarse grained approach, I describe the stochastic growth of such neurons as a dynamical population system. Secondly, I aim to show how tension and an exploration-exploitation system converges to a near-optimal spatial coverage. I also compare class IV with class I neurons to describe cytoskeletal “memory” mechanisms that may constrain or sustain branch growth.
