Salmonella is a pathogen posing a significant threat to public health. At the onset of the immune response neutrophils target, phagocytose, and attack Salmonella with various reactive chemical species. Salmonella can withstand this immune onslaught, and it is this survival under neutrophil oxidative stress we aim to understand. Specifically, we aim to elucidate the response mechanisms to a particular, less understood, reactive species produced by neutrophils. For this, we are employing an interdisciplinary approach, based around wet lab fluorescence microscopy and microfluidics to follow spatio-temporal gene regulatory and morphological dynamics paired to mathematical modelling to further drive understanding of how Salmonella are able to withstand this most basic of human defenses.