INTERNAL SEMINAR – Delphine Delacour (IBDM)

Delphine Delacour (IBDM) will give a short internal seminar.

This seminar will take place at the Hexagone Auditorium.
CENTURI is also providing for off-campus participants only a zoom link to attend the seminar: https://us02web.zoom.us/j/85941690095?pwd=Nm5NVGhESGlUbG1FMnZ2dU5vSlkxUT09

Title: Biomechanics of the Gut Epithelium Development

Abstract: Deciphering the dynamic cell orchestration that conditions faithful mammalian organogenesis is a critical and unresolved challenge. In this study, we focus on the mammalian gut—a highly organized monolayer epithelium where adult tissue self-renewal is driven by stem cell divisions within a specialized niche (Saleh et al., Developmental Cell, 2023). Biomechanics may play a pivotal role in coordinating cellular activities, thereby maintaining the integrity and architecture of the epithelium. To gain a comprehensive understanding of gut epithelial dynamics, we advocate for a multiscale, integrative approach that combines high-resolution live imaging with advanced analytical techniques. We aim to: 1) identify key events driving the dynamics of the gut’s epithelium by integrating in vivoand ex vivo advanced imaging, biomechanical analysis, and physical modeling, and 2) experimentally perturb the system to uncover the cellular, tissue, and molecular mechanisms that regulates gut epithelial dynamics. This approach will yield valuable insights into the intricate processes that govern tissue homeostasis and development in the gut, deepening our understanding of epithelial biology and its implications for health and disease.

Meeting ID: 859 4169 0095
Secret Code: 002024