EXTERNAL SEMINAR - Lisa Manning (Syracuse University)

Lisa Manning (Syracuse University) will give a short external seminar, hosted by Thomas Lecuit (IBDM) and Matthias Merkel (CPT).

This seminar will take place in the Hexagone Auditorium.
CENTURI is also providing for off-campus participants only a zoom link to attend the seminar: https://us02web.zoom.us/j/85941690095?pwd=Nm5NVGhESGlUbG1FMnZ2dU5vSlkxUT09

Meeting ID: 859 4169 0095
Secret Code: 002024

Title: Self-generated dynamical forces shape cells and organs in the zebrafish embryo

 

Abstract: We aim to understand the mechanisms that control precise cell and tissue shape changes required for organ function. Many studies focused on cell shapes have ignored the role of dynamic forces self-generated by slow tissue flows, but recent work showing tissues are near a jamming transition with diverging relaxation timescales suggests slow motion could give rise to large forces.  Through a combination of mathematical modeling, imaging, and mechanical perturbations to in vivo experiments, our work demonstrates that tissue-scale dynamic forces are sculpting the shape of an epithelial organ in the zebrafish embryo called Kupffer’s vesicle (KV). Because there are many processes during development that occur at similarly slow rates, this suggests that self-generated dynamic forces perhaps should be investigated more broadly.